Immunoinformatics Approach to T-cell Epitopes in Human Immunodeficiency Virus

Authors

  • Deepa Chaturvedi Department of Biotechnology, Invertis University, NH-24, Bareilly – 243123 U.P INDIA
  • Mallika Pandey Department of Biotechnology, Invertis University, NH-24, Bareilly – 243123 U.P INDIA
  • Vijai Singh Department of Biotechnology, Invertis University, NH-24, Bareilly – 243123 U.P INDIA
  • Ravi Deval Department of Biotechnology, Invertis University, NH-24, Bareilly – 243123 U.P INDIA

Keywords:

HIV, AIDS, Virulence Protein, Epitope, MHC, Vaccine

Abstract

Human immunodeficiency virus (HIV) is major human disease which belongs to lentivirus (retrovirus). It is a major cause of acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life threatening opportunistic infections and cancers to thrive. A number of ways for transmission of HIV form human to another human through the blood, semen, vaginal fluid, pre-ejaculate or breast milk has been proved. An urgent need arises to establish antigen based immunodiagnostic for earlier monitoring of HIV and development of vaccines. In the present study, we have identified two major proteins i.e. ENV and NEF for identification of T-cell epitopes. We used two well established immunoinformatics tools Propred and Propred1 for identification. We identified a novel T-cell epitope for major histocompatibility complex class I and II with highest binding affinity. These finding provide a new insight for development of antigen based diagnostic kit and peptide based vaccine designing for controlling of AIDS.

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Published

31-12-2013

Issue

Section

Articles

How to Cite

Chaturvedi, D., Pandey, M., Singh, V., & Deval, R. (2013). Immunoinformatics Approach to T-cell Epitopes in Human Immunodeficiency Virus. G-Journal of Environmental Science and Technology, 1(3), 57-61. https://gjestenv.com/index.php/gjest/article/view/20

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